CALL FOR PAPERS Functional Analysis of Sequence Variation H55N polymorphism as a likely cause of variation in citrate synthase activity of mouse skeletal muscle
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چکیده
Aivaras Ratkevicius, Andrew M. Carroll, Audrius Kilikevicius, Tomas Venckunas, Kevin T. McDermott, Stuart R. Gray, Henning Wackerhage, and Arimantas Lionikas School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom; and Department of Applied Physiology and Kinesiotherapy, Lithuanian Academy of Physical Education, Kaunas, Lithuania
منابع مشابه
H55N polymorphism as a likely cause of variation in citrate synthase activity of mouse skeletal muscle.
Citrate synthase (CS) is an enzyme of the Krebs cycle that plays a key role in mitochondrial metabolism. The aim of this study was to investigate the mechanisms underlying low activity of citrate synthase (CS) in A/J mice compared with other inbred strains of mice. Enzyme activity, protein content, and mRNA levels of CS were studied in the quadriceps muscles of A/J, BALB/cByJ, C57BL/6J, C3H/HeJ...
متن کاملH55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells
The H55N polymorphism in the Cs gene of A/J mice has been linked to low activity of the enzyme in skeletal muscles. The aim of the study was to test this hypothesis and examine effects of low citrate synthase (CS) activity on palmitate metabolism in muscle cells. Results of the study showed that carriers of the wild type (WT) Cs (C57BL/6J and Balb/cByJ mouse strains) had higher CS activity (p <...
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متن کاملبررسی نقش پیروات دهیدروژناز کیناز 4 (PDK4) بر بیان سیترات سنتاز در عضله اسکلتی متعاقب چهار هفته تمرین استقامتی در موشهای نر نژاد ویستار
Background and Objective: Maintaining a balance between energy demand and supply is critical for health. In this process, pyruvate dehydrogenase kinase 4 (PDK4) enzyme plays an important role to maintain energy homeostasis. So, the aim of the present study was to investigate the role of PDK4 on the expression of citrate synthase in the skeletal muscle after 4 weeks of endurance training in male...
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تاریخ انتشار 2010